Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 3, Pages 1278-1283Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c11641
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21788102, 91853201, 21722801, 81673489, 31871414]
- National Science and Technology Major Project of China [2018ZX10732202]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- International Cooperation Program of Shanghai Science and Technology Committee [17520750100]
- Fundamental Research Funds for the Central Universities [222201717003]
- National Institutes of Health [R01 GM103790]
- Robert A. Welch Foundation [F-0018]
Ask authors/readers for more resources
In this study, fluorescent deferasirox derivatives with unique photophysical properties were reported, and a fluorescent responsive pro-chelator was successfully developed for the detection of alkaline phosphatase. The diagnostic potential of these deferasirox derivatives in bacterial biofilm studies was demonstrated.
Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available