4.8 Article

Dual Catalytic Strategy for Forging sp2-sp3 and sp3-sp3 Architectures via β-Scission of Aliphatic Alcohol Derivatives

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 49, Pages 20594-20599

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c11172

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Funding

  1. ICIQ
  2. FEDER/MCI [AEI/PGC2018-096839-BI00]
  3. MCI/AEI (Severo Ochoa Excellence Accreditation 2020-2023) [CEX2019-000925-S]
  4. European Union's Horizon 2020 under the Marie Curie PREBIST grant [754558]

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A dual platform for forging sp(2)-sp(3) and sp(3)-sp(3) carbon bonds via catalytic beta-scission of aliphatic alcohol derivatives with both aryl and alkyl halides is disclosed. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization.

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