Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 3, Pages 1296-1300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c12044
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Funding
- National Science Foundation (DMR) [2004947]
- National Institute of General Medical Sciences [1R01GM121612]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [2004947] Funding Source: National Science Foundation
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A self-assembled, skin-depigmenting SNA structure was reported in this study, showing a reduction in melanin content in melanoma cells and a potent antimelanogenic effect in an ultraviolet B-induced hyperpigmentation mouse model.
Oligonucleotide-based materials such as spherical nucleic acid (SNA) have been reported to exhibit improved penetration through the epidermis and the dermis of the skin upon topical application. Herein, we report a self-assembled, skin-depigmenting SNA structure, which is based upon a bifunctional oligonucleotide amphiphile containing an antisense oligonucleotide and a tyrosinase inhibitor prodrug. The two components work synergistically to increase oligonucleotide cellular uptake, enhance drug solubility, and promote skin penetration. The particles were shown to reduce melanin content in B16F10 melanoma cells and exhibited a potent antimelanogenic effect in an ultraviolet B-induced hyperpigmentation mouse model.
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