Fluoroarene Separations in Metal-Organic Frameworks with Two Proximal Mg2+ Coordination Sites

Fluoroarenes are widely used in medicinal, agricultural, and materials chemistry, and yet their production remains a critical challenge in organic synthesis. Indeed, the nearly identical physical properties of these vital building blocks hinders their purification by traditional methods, such as flash chromatography or distillation. As a result, the Balz-Schiemann reaction is currently employed to prepare fluoroarenes instead of more atom-economical C-H fluorination reactions, which produce inseparable mixtures of regioisomers. Herein, we propose an alternative solution to this problem: the purification of mixtures of fluoroarenes using metal-organic frameworks (MOFs). Specifically, we demonstrate that controlling the interaction of fluoroarenes with adjacent coordinatively unsaturated Mg2+ centers within a MOF enables the separation of fluoroarene mixtures with unparalleled selectivities. Liquid-phase multicomponent equilibrium adsorption data and breakthrough measurements coupled with van der Waals-corrected density functional theory calculations reveal that the materials Mg-2(dobdc) (dobdc(4-) = 2,5-dioxidobenzene-1,4-dicarboxylate) and Mg-2(m-dobdc) (m-dobdc(4-) = 2,4-dioxidobenzene-1,5-dicarboxylate) are capable of separating the difluorobenzene isomers from one another. Additionally, these frameworks facilitate the separations of fluoroanisoles, fluorotoluenes, and fluorochlorobenzenes. In addition to enabling currently unfeasible separations for the production of fluoroarenes, our results suggest that carefully controlling the interaction of isomers with not one but two strong binding sites within a MOF provides a general strategy for achieving challenging liquid-phase separations.

Automated summary

Fluoroarenes are widely used in various fields but their production remains a challenge due to their similar physical properties hindering purification. Current methods using the Balz-Schiemann reaction are less efficient than C-H fluorination reactions. Research shows that using metal-organic frameworks (MOFs) can enable selective separation of fluoroarene mixtures, providing a general strategy for challenging liquid-phase separations.