4.3 Article

Transepithelial Corneal Cross-Linking With Supplemental Oxygen in Keratoconus: 1-Year Clinical Results

Journal

JOURNAL OF REFRACTIVE SURGERY
Volume 37, Issue 1, Pages 42-48

Publisher

SLACK INC
DOI: 10.3928/1081597X-20201111-01

Keywords

-

Ask authors/readers for more resources

Transepithelial CXL performed in an oxygen-rich atmosphere results in improved Kmax and CDVA with good safety. The most frequent adverse event was corneal haze.
PURPOSE: To evaluate the efficacy and safety of transepithelial corneal cross-linking (CXL) with supplemental oxygen. METHODS: This was a prospective, non-comparative, pilot cohort study conducted at the National Reference Center for Keratoconus (Toulouse, France) on patients with progressive keratoconus. Transepithelial, pulsed, accelerated CXL was performed in an oxygen-rich atmosphere. Oxygen goggles were applied to the eyes to maintain a high level of oxygen during treatment. The main efficacy outcome was the mean change from baseline in maximum keratometry (Kmax) and the secondary outcomes were the mean changes in flat keratometry (K1), steep keratometry (K2), mean keratometry (Km), corrected distance visual acuity (CDVA), uncorrected distance visual acuity (UDVA), and demarcation line depth. The safety outcomes were the incidence of adverse events, the mean change in pachymetry, and endothelial cell. count. RESULTS: Thirty-four eyes of 34 patients were included. At 12 months postoperatively, the Kmax decreased by 1.56 +/- 1.71 diopters (D) (P < .0001) and CDVA improved by 0.093 +/- 0.193 logMAR (P < .02). The K2 and Km decreased by 0.51 +/- 1.03 (P < .02) and 0.40 +/- 0.78 D (P < .01), respectively. There was no change in K1 and UDVA. The most frequent adverse event was corneal haze (64.78%). There were neither cases of infectious keratitis or toss of more than two lines in CDVA nor changes in pachymetry or endothelial cell count. CONCLUSIONS: Transepithelial CXL performed in an oxygenrich atmosphere results in improved Kmax and CDVA with good safety. These promising findings suggest that this procedure could be safe and capable of halting the progression of keratoconus.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available