Journal
DIGESTIVE SURGERY
Volume 33, Issue 4, Pages 343-350Publisher
KARGER
DOI: 10.1159/000445020
Keywords
Pancreas cancer; Chemotherapy; Radiotherapy; Chemoradiation; Combined modality therapy
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Pancreatic ductal adenocarcinoma (PDAC) is increasingly common and a leading cause of cancer-related mortality. Surgery remains the only possibility for cure. Upwards of 40% of patients present with locally advanced PDAC (LA-PDAC), where management strategies continue to evolve. In this review, we highlight current trends in neoadjuvant chemotherapy, surgical resection, and other multimodality approaches for patients with LA-PDAC. Despite promising early results, additional work is needed to more accurately and appropriately tailor treatment for patients with LA-PDAC. (C) 2016 S. Karger AG, Basel
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