☆ 4.6 Editorial Material

Increased intestinal phosphate absorption, an often-overlooked effect of vitamin D

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Neurosciences

1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine

Nati Hernando et al.

Summary: Intestinal absorption of phosphate is primarily mediated by the active transcellular pathway involving NaPi-IIb, stimulated by 1,25(OH)(2) vitamin D-3. The effects of hormonal regulation on other targets besides NaPi-IIb remain unknown. Administration of 1,25(OH)(2) vitamin D-3 in mice resulted in increased active transport of phosphate specifically in the jejunum, with no effect on the paracellular pathway. Both wild-type and Slc34a2-deficient mice showed similar responses to 1,25(OH)(2) vitamin D-3 in terms of hyperphosphaturia and changes in FGF23 and PTH levels.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Medicine, Research & Experimental