Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 403, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2020.112846
Keywords
photosensitizer; singlet oxygen; pH; near-infrared; activatable
Categories
Funding
- JSPS KAKENHI [JP 19K05688]
- Medical Innovation Project of Gunma University
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To achieve highly selective tumor therapy and diagnosis, we have developed a novel low-pH-activatable photosensitizer, AI(4)P, which is a porphyrin derivative possessing four 5-diethylaminoindole units. These 5-diethylaminoindole units enhance internal conversion from the first excited singlet state to suppress fluorescence and photosensitization of singlet oxygen. Upon decreasing pH, AI(4)P becomes protonated form. This protonated form exhibited strong absorption at 740 nm, which is the optimal wavelength for light penetration through living tissues. In addition, the pmtonated form exhibited efficient fluorescence and photosensitization. Therefore, AI(4)P is proposed as a triply activatable near-infrared photosensitizer that can activate near-infrared absorption, fluorescence, and photosensitization simultaneously. The activation ratio was over 200, which represents almost complete activation.
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