Impact of adjunctive procedures on recombinant human fibroblast growth factor (rhFGF-2) mediated periodontal regeneration therapy: A retrospective study

Background Human fibroblast growth factor-2 (rhFGF-2) therapy has been used for periodontal tissue regeneration. However, few studies have reported their adjunctive procedures based on strategy of tissue engineering. The aim of this retrospective study is to assess the adjunctive effects of modified papilla preservation technique (mPPT) and combination with autogenous bone grafts (AG) on the rhFGF-2 therapy. Methods Total of 44 sites underwent rhFGF-2 therapies and the evaluations in the survey periods. The primary outcome was set to the radiographic bone fill by radiographic examinations at 6 and 12 months after surgeries. We analyzed the correlation between influencing factors and the primary outcome, and differences of therapeutic effect by combination therapy with mPPT and that with AG. Results After surgeries, probing depth (PD), clinical attachment level (CAL) and bone defects significantly improved. The improvements of radiographic bone fill were significantly positive correlated with a number of bone walls, combination with mPPT, and AG at 6 months after surgeries, and with combination with mPPT and AG at 12 months after surgeries. The significant differences of improvements of radiographic bone fill were demonstrated between combination with or without mPPT at 12 months after surgeries, and with or without AG at 6 and 12 months after surgeries. Moreover, the multiple linear regression analysis for the radiographic bone fill indicated the significant regression coefficient with conducts of mPPT. Conclusions mPPT and AG had powerfully adjunctive effects on rhFGF-2 therapy. Further studies are needed in order to verify by randomized clinical trials.

Automated summary

Modified papilla preservation technique (mPPT) and autogenous bone grafts (AG) act as powerful adjunctive effects on rhFGF-2 therapy, significantly improving probing depth (PD), clinical attachment level (CAL), and bone defects. The combination of mPPT and AG shows positive correlations with improvements in radiographic bone fill, highlighting the importance of these adjunctive procedures in periodontal tissue regeneration. More studies are needed to confirm these findings through randomized clinical trials.