Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 2, Pages 1964-1971Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02497
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Funding
- National S&T Major Project of China [2018ZX09201011]
- Science & Technology Development Fund of Tianjin Education Commission for Higher Education [2017KJ138]
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The additive-free copper(I)-bromide-mediated radical cyclization reactions of alpha,alpha-dibromo beta-iminoesters successfully enabled the synthesis of a series of 5- or 6-brominated 2-aryl-1H-indole-3-carboxylates in moderate to good yields. Mechanistic study revealed the bromine atom originated from the substrates and the bromination might be related to a 3-bromo-3H indole intermediate.
Additive-free copper(I)-bromide-mediated radical cyclization reactions of alpha,alpha-dibromo beta-iminoesters were investigated, enabling the synthesis of a series of 5- or 6-brominated 2-aryl-1H-indole-3-carboxylates in moderate to good yields. The mechanistic study showed that (i) the bromine atom originated from the substrates and (ii) the bromination might be related to a 3-bromo-3H indole intermediate via an electrophilic bromine atom transfer. Furthermore, the practicality of this method was demonstrated by gram-scale synthesis and the potential for product derivatization toward other valuable multisubstituted indoles.
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