Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 2, Pages 1948-1954Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02364
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Funding
- SERB, DST inspire faculty award [CRG/2019/002319, DST/INSPIRE/04/2015/000785]
- Indian Institute of Science (IISc) start-up research grant
- IISc Bangalore
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This study presents a new mild borylation reaction method using iron-bis amide mediated boronating agent for alkyl bromides and chlorides. The reaction shows a wide substrate scope and good functional group compatibility, with sufficient catalytic activity for primary and secondary alkyl halides. Mechanistic studies suggest that the reaction proceeds through a radical pathway.
The mild borylation of alkyl bromides and chlorides with bis(neopentylglycolato)diborane (B(2)neop(2)) mediated by iron-bis amide is described. The reaction proceeds with a broad substrate scope and good functional group compatibility. Moreover, sufficient catalytic activity was obtained for primary and secondary alkyl halides. Mechanistic studies indicate that the reaction proceeds through a radical pathway.
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