Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents

The mild borylation of alkyl bromides and chlorides with bis(neopentylglycolato)diborane (B(2)neop(2)) mediated by iron-bis amide is described. The reaction proceeds with a broad substrate scope and good functional group compatibility. Moreover, sufficient catalytic activity was obtained for primary and secondary alkyl halides. Mechanistic studies indicate that the reaction proceeds through a radical pathway.

Automated summary

This study presents a new mild borylation reaction method using iron-bis amide mediated boronating agent for alkyl bromides and chlorides. The reaction shows a wide substrate scope and good functional group compatibility, with sufficient catalytic activity for primary and secondary alkyl halides. Mechanistic studies suggest that the reaction proceeds through a radical pathway.