Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 1, Pages 917-928Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02429
Keywords
-
Categories
Funding
- Fundamental Research Funds for the Central Universities [2232020A-09]
- National Science Foundation of China [NSFC-21804018]
- National Science Foundation of Shanghai [19ZR1470800]
Ask authors/readers for more resources
A green method for synthesizing spiro[4.5]trienones through electrochemical oxidative halocyclization with N-aryl alkynamides was developed without the need for metal catalysts or external oxidants. Using LiCl, LiBr, and LiI as halogen sources, a variety of dearomative halo-spirocyclization products were obtained in good to excellent yields with a broad scope and functional group tolerance.
We developed a green method for the synthesis of spiro[4.5]trienones through an electrochemical oxidative halocyclization with N-aryl alkynamides. This reaction was conducted under metal-catalyst- and exogenous-oxidant-free conditions at room temperature. Using readily available LiCl, LiBr, and LiI as the halogen source, a variety of dearomative halo-spirocyclization products were obtained in good to excellent yields with a broad scope and functional group tolerance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available