Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 3, Pages 2827-2839Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02779
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Funding
- National Key Research Project [2017YFA0506000]
- National Natural Science Foundation of China [22077096, 21807080]
- Natural Science Foundation of Zhejiang Province [LQ18B020004]
- Wenzhou Medical University Research Start-up Fund [QTJ17007]
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This study achieved the synthesis of 7-amido indoles via regioselective C-H bond functionalization under Ru(II) catalysis, with a wide range of applicable substrates and good conversion yields. Deuteration studies and control experiments were conducted to elucidate the mechanism of this transformation.
A protocol for the preparation of 7-amido indoles via regioselective C-H bond functionalization has been first accomplished under Ru(II) catalysis. Indole derivatives and 4-aryl/heteroaryl/benzyl/alkyl dioxzaolines containing various substituents were applicable for this transformation, readily providing the amidated indoles in moderate to good yields. This novel process has many advantages, including good compatibility with diverse functional groups, broad substrate scopes, and mild reaction conditions. Deuteration studies and control experiments have been performed to understand the mechanism of this transformation.
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