Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 3, Pages 2107-2116Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.0c02254
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- CSIR, New Delhi, India
- CSIR, New Delhi [CSIR/21(1110)/20/EMR-II]
- DST
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A highly regioselective synthesis of substituted hemiaminal is achieved via metal-free addition of ethers to quinone imine ketals (QIKs) in the presence of tetrabutylammonium chloride and potassium persulfate (K2S2O8). This strategy provides an easy access to substituted hemiaminal ethers with high functional group tolerance in good to excellent yields.
The highly regioselective synthesis of substituted hemiaminal via addition of ethers to quinone imine ketals (QIKs) has been developed under metal-free conditions. In the presence of tetrabutylammonium chloride and potassium persulfate (K2S2O8), QIKs couple efficiently with cyclic and acyclic ethers to give hemiaminals. This strategy offers an easy access to substituted hemiaminal ethers with high functional group tolerance in good to excellent yields.
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