Journal
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 41, Issue 7, Pages 1139-1144Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01443615.2020.1845630
Keywords
HPV; anal cytology; cervical intraepithelial neoplasia
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Funding
- units of dermatology, microbiology, surgical pathology and biostatistics of La Paz University Hospital
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The study found that there is a certain association between anal HPV infection and abnormal anal cytology with high-grade cervical intraepithelial neoplasia, but there was no statistically significant difference compared to women with CIN 1 or no cervical dysplasia. Apart from HPV infection, immunosuppression, cervical HPV infection, and being older than 40 were also associated with anomalous anal results.
Our aim was to analyze the association between anal human papillomavirus (HPV) infection and abnormal anal cytology in women with high-grade cervical intraepithelial neoplasia (CIN 2+). We also analysed what other risk factors might be significant. We carried out a prevalence study from April 2015 to March 2017 at La Paz University Hospital. Genotyping of HPV, anal cytology and high-resolution anoscopy were performed. Of 171 patients recruited, 53 cases (31%) were diagnosed as histological CIN 2+: there were no statistically significant differences in the prevalence of anal HPV (OR = 0.8), nor the prevalence of abnormal anal cytology (OR = 2.15, 95% CI 0.8-5.7) compared to women with CIN 1 or no cervical dysplasia. Immunosuppression (OR = 2.51, 95% CI 1-6.3, p < .05), cervical HPV (OR = 3.9, 95% CI 1.9-8.0, p < .01) and being older than 40 years old (p < .05) were also associated with anomalous anal results.
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