Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 99, Issue 4, Pages 1024-1047Publisher
WILEY
DOI: 10.1002/jnr.24776
Keywords
blood-brain barrier; glioblastoma; photodynamic therapy; resistance mechanisms; tumor microenvironment
Categories
Funding
- Secretaria de Ciencia y Tecnica, Universidad Nacional de Rio Cuarto
- Consejo Nacional de Investigaciones Cientificas y Tecnicas
- Agencia Nacional de Promocion Cientifica y Tecnologica
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PDT is a therapeutic approach that involves the destruction of tumor cells by reactive oxygen species induced by light after prior treatment with a photosensitizing agent. Recent advances have expanded its experimental application to other effects that could enhance overall performance against GBM.
Photodynamic therapy (PDT) has recently gained attention as an alternative treatment of malignant gliomas. Glioblastoma (GBM) is the most prevalent within tumors of the central nervous system (CNS). Conventional treatments for this CNS tumor include surgery, radiation, and chemotherapy. Surgery is still being considered as the treatment of choice. Even so, the poor prognosis and/or recurrence of the disease after applying any of these treatments highlight the urgency of exploring new therapies and/or improving existing ones to achieve the definitive eradication of tumor masses and remaining cells. PDT is a therapeutic modality that involves the destruction of tumor cells by reactive oxygen species induced by light, which were previously treated with a photosensitizing agent. However, in recent years, its experimental application has expanded to other effects that could improve overall performance against GBM. In the current review, we revisit the main advances of PDT for GBM management and also, the recent mechanistic insights about cellular and molecular aspects related to tumoral resistance to PDT of GBM.
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