4.7 Article

Frontotemporal Regulation of Subjective Value to Suppress Impulsivity in Intertemporal Choices

Journal

JOURNAL OF NEUROSCIENCE
Volume 41, Issue 8, Pages 1727-1737

Publisher

SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1196-20.2020

Keywords

delay discounting; eye tracking; frontal cortex; high-frequency activity; impulsivity; MEG

Categories

Funding

  1. National Institute of Neurological Disorders and Stroke [R37NS21135, DFG/SFB 779]

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The study found that impulsive decisions often prioritize smaller but sooner rewards compared to larger but later rewards, and the contribution of neural activity and attention to choice alternatives to reward decisions is not yet clear.
Impulsive decisions arise from preferring smaller but sooner rewards compared with larger but later rewards. How neural activity and attention to choice alternatives contribute to reward decisions during temporal discounting is not clear. Here we probed (1) attention to and (2) neural representation of delay and reward information in humans (both sexes) engaged in choices. We studied behavioral and frequency-specific dynamics supporting impulsive decisions on a fine-grained temporal scale using eye tracking and MEG recordings. In one condition, participants had to decide for themselves but pretended to decide for their best friend in a second prosocial condition, which required perspective taking. Hence, conditions varied in the value for themselves versus that pretending to choose for another person. Stronger impulsivity was reliably found across three independent groups for prosocial decisions. Eye tracking revealed a systematic shift of attention from the delay to the reward information and differences in eye tracking between conditions predicted differences in discounting. High-frequency activity (175-250Hz) distributed over right frontotemporal sensors correlated with delay and reward information in consecutive temporal intervals for high value decisions for oneself but not the friend. Collectively, the results imply that the high-frequency activity recorded over frontotemporal MEG sensors plays a critical role in choice option integration.

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