Journal
JOURNAL OF NEUROSCIENCE
Volume 41, Issue 5, Pages 845-854Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1654-20.2020
Keywords
interneuron; plasticity; propriospinal; spinal cord
Categories
Funding
- Lisa Dean Moseley Foundation
- Pew Charitable Trust
- Whitehall Foundation
- New Jersey Commission on Spinal Cord Research
- Craig H. Neilsen [649984, 465068]
- Roddenberry Foundation
- National Institutes of Health [NS111643, NS112959, R01 NS089324, R01 NS104291]
- Frederick W. and Joanne J. Mitchell Chair in Molecular Biology
- Wings for Life Spinal Cord Research Foundation
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Spinal interneurons play a crucial role in the intact CNS, contributing to the control and modulation of motor, sensory, and autonomic functions, with potential changes following traumatic spinal cord injury. Treatments optimizing the contribution of interneurons to functional improvement are also discussed.
Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.
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