Related references
Note: Only part of the references are listed.Targeting Huntingtin Expression in Patients with Huntington's Disease
Sarah J. Tabrizi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
A novel and potent brain penetrant inhibitor of extracellular vesicle release
Camilo Rojas et al.
BRITISH JOURNAL OF PHARMACOLOGY (2019)
HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Dagmar E. Ehrnhoefer et al.
HUMAN MOLECULAR GENETICS (2018)
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
Dagmar E. Ehrnhoefer et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)
Therapeutic approaches to Huntington disease: from the bench to the clinic
Nicholas S. Caron et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease
Lauren M. Byrne et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Amber L. Southwell et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Humberto Mestre et al.
ELIFE (2018)
Targeted delivery of antisense oligonucleotides to pancreatic β-cells
C. Ammala et al.
SCIENCE ADVANCES (2018)
Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway
Katarina Trajkovic et al.
JOURNAL OF NEUROSCIENCE (2017)
Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis
Lauren M. Byrne et al.
LANCET NEUROLOGY (2017)
Neurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington's disease R6/2 mice
Rana Soylu-Kucharz et al.
SCIENTIFIC REPORTS (2017)
Human-to-mouse prion-like propagation of mutant huntingtin protein
Iksoo Jeon et al.
ACTA NEUROPATHOLOGICA (2016)
Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture
Xuan Zhang et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)
Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease
Filipe Brogueira Rodrigues et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients
Edward J. Wild et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1
Gwen E. Owens et al.
JOURNAL OF MOLECULAR BIOLOGY (2015)
Transcellular spreading of huntingtin aggregates in the Drosophila brain
Daniel T. Babcock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression
Amber L. Southwell et al.
SCIENTIFIC REPORTS (2015)
Mutant Huntingtin is Present in Neuronal Grafts in Huntington Disease Patients
Francesca Cicchetti et al.
ANNALS OF NEUROLOGY (2014)
Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane
Hemma Brandstaetter et al.
DISEASE MODELS & MECHANISMS (2014)
Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease
Lisa M. Stanek et al.
HUMAN GENE THERAPY (2014)
In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides
Amber L. Southwell et al.
MOLECULAR THERAPY (2014)
Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons
Eline Pecho-Vrieseling et al.
NATURE NEUROSCIENCE (2014)
Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients
Niels H. Skotte et al.
PLOS ONE (2014)
A fully humanized transgenic mouse model of Huntington disease
Amber L. Southwell et al.
HUMAN MOLECULAR GENETICS (2013)
Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes
Maddalena Costanzo et al.
JOURNAL OF CELL SCIENCE (2013)
Antisense Oligonucleotide-Mediated Correction of Transcriptional Dysregulation is Correlated with Behavioral Benefits in the YAC128 Mouse Model of Huntington's Disease
Lisa M. Stanek et al.
JOURNAL OF HUNTINGTONS DISEASE (2013)
Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis
Holly B. Kordasiewicz et al.
NEURON (2012)
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Jeffrey J. Iliff et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene/Allele-Specific Silencing of Mutant Huntingtin
Jeffrey B. Carroll et al.
MOLECULAR THERAPY (2011)
Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
Erich Koller et al.
NUCLEIC ACIDS RESEARCH (2011)
Increased levels of total tau protein in the cerebrospinal fluid in Huntington's disease
Radu Constantinescu et al.
PARKINSONISM & RELATED DISORDERS (2011)
Huntingtin facilitates polycomb repressive complex 2
Ihn Sik Seong et al.
HUMAN MOLECULAR GENETICS (2010)
Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington's disease
Andreas Weiss et al.
ANALYTICAL BIOCHEMISTRY (2009)
Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease
Amber L. Southwell et al.
JOURNAL OF NEUROSCIENCE (2009)
Levels of the light subunit of neurofilament triplet protein in cerebrospinal fluid in Huntington's disease
Radu Constantinescu et al.
PARKINSONISM & RELATED DISORDERS (2009)
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
Michelle Gray et al.
JOURNAL OF NEUROSCIENCE (2008)
AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease
Nicholas R. Franich et al.
MOLECULAR THERAPY (2008)
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits
M. DiFiglia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space
Anne N. T. Strehlow et al.
HUMAN MOLECULAR GENETICS (2007)
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
Rona K. Graham et al.
CELL (2006)
rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse
Y Machida et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA
YL Wang et al.
NEUROSCIENCE RESEARCH (2005)
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice
E Rodriguez-Lebron et al.
MOLECULAR THERAPY (2005)
RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model
SQ Harper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1
K Oshio et al.
FASEB JOURNAL (2004)
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow et al.
HUMAN MOLECULAR GENETICS (2003)
A linear lattice model for polyglutamine in CAG-expansion diseases
MJ Bennett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Share Paper
