Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1224, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2020.129179
Keywords
Chemosensor for Zn2+; MTT assay; Live cell imaging studies; INHIBIT logic gate; DFT calculation
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Funding
- CSIR, New Delhi, India [01(2992)/19/EMR-II]
- UGC-India
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The new fluorescence probe H2L shows efficient and selective detection of Zn(II), with low toxicity and potential for live cell imaging.
A new fluorescence probe (H2L) is designed and synthesized for efficient and selective detection of Zn(II). H2L exhibits a turn-on fluorescence response with substantial enhancement of emission intensity with Zn2+ even in presence of other coexisting cations found in various environmental and biological samples. The calculated value of limit of detection (LOD) is 1.73 x 10(-9) M. Exploiting the reversibility of the probe in presence of EDTA, an INHIBIT logic gate is constructed with Zn2+ and EDTA as chemical inputs. DFT and TDDFT calculations are used to interpret electronic structures and elucidate the sensing mechanism. Cytotoxicity study by MTT method with human breast cancer cell lines (MCF-7) reveals that H2L has negligible toxicity in low concentration levels and can be effectively used for live cell imaging. (C) 2020 Elsevier B.V. All rights reserved.
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