In neutralized medium five new Ca(II), Zn(II), Fe(III), Au(III) and Pd(II) complexity of ceftriaxone antibiotic drug: Synthesis, spectroscopic, morphological and anticancer studies

A five ceftriaxone antibiotic (ctx) complexes with Ca(II), Zn(II), Au(III) and Pd(II) metal ions were synthe sized by 1:1 M ratio between of ceftriaxone hydrated sodium salt (Na(2)ctx) with CaCl2, ZnCl2, FeCl3 center dot 6H(2)O, AuCl3 and PdCl2 metal salts in water-methanol medium. The complexes were well characterized dependent on the microanalytical (C,H, N), molar conductance, (FTIR. Raman, (HNMR)-H-1 and UV-Vis) spectroscopies, and magnetic measurements. The surface morphology and calculation of particle size of ceftriaxone complexes were performed based on SEM, TEM and X-ray diffraction. Calcium(II), zinc(II), and iron(III) complexes are six-coordinate with distorted octahedral geometry, while gold(III) and palladium(II) are four-coordination mode. The ceftriaxone drug acts as a tetradentate ligand towards five metal ions through N (amino group) and O (triazine, beta-lactam carbonyl, and carboxylate groups) with the molecular formulas [Ca(ctx)(H2O)(2)]center dot 5H(2)O (1), [Zn(ctx)(H2O)(2)]center dot 7H(2)O (2), [Fe(ctx)(H2O)(Cl)]center dot 7H(2)O (3), [Au(ctx)]center dot Cl center dot 4H(2)O (4) and [Pd(ctx)]center dot 3H(2)O (5). The cytotoxidty assays study of gold(III) complex against colon carcinoma cells (HCT-116) and hepatocellular carcinoma cells (HepG-2) showed that the 50% inhibitory concentration (IC50) of [Au(ctx)]center dot Cl center dot 4H(2)O against HepG-2 cell line is 8.53 mu g higher than that of HCT-116 cell line 20.5 mu g. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

This study synthesized five ceftriaxone complexes with various metal ions, characterized them, and conducted cytotoxicity experiments, showing gold(III) complex has higher toxicity against HepG-2 cells compared to HCT-116 cells.