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Anne B. Eldrup et al.
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Ding Ai et al.
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Action of epoxyeicosatrienoic acids on cellular function
Arthur A. Spector et al.
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GA Gomez et al.
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Y Liu et al.
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IH Kim et al.
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IH Kim et al.
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KJ Barnham et al.
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MS Butler
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JW Newman et al.
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BD Przybyla-Zawislak et al.
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QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds
NR McElroy et al.
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A Klegeris et al.
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A Cronin et al.
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JW Newman et al.
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JR Falck et al.
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JE Morley et al.
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DL Kroetz et al.
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C Morisseau et al.
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PL Li et al.
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S Wilhelm et al.
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K Node et al.
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X Fang et al.
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DH Munzenmaier et al.
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Hepatic and pulmonary enzyme activities in horses
J Lakritz et al.
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