Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 1, Pages 101-122Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.0c01307
Keywords
-
Categories
Ask authors/readers for more resources
Inhibiting NLRP3 inflammasome has shown to regulate inflammation in preclinical models, with companies initiating clinical testing of direct NLRP3 inhibitors. The NLRP3 inflammasome is part of a larger pro-inflammatory pathway, and modulation of this pathway is also under exploration. Multiple targets in this pathway have been targeted by molecules through clinical trials.
Inhibiting the NLRP3 inflammasome mediates inflammation in an extensive number of preclinical models. As excitement in this field has grown, several companies have recently initiated testing of direct NLRP3 inhibitors in the clinic. At the same time, the NLRP3 inflammasome is part of a larger pro-inflammatory pathway, whose modulation is also being explored. Multiple targets in this pathway are already impinged upon by molecules that have been through clinical trials. These data, informed by the growing mechanistic understanding of the NLRP3 inflammasome in the preclinical space, provide a rich backdrop to assess the current state of the field. Here we explore attempts to inhibit the NLRP3 inflammasome in light of clinical and preclinical data around efficacy and safety.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available