4.6 Article

Boron dipyrromethene-based near-infrared fluorescent probe for the selective imaging and analyzing hydrogen peroxide in living cells

Journal

JOURNAL OF LUMINESCENCE
Volume 229, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.jlumin.2020.117642

Keywords

Fluorescent probe; Hydrogen peroxide; Turn-on fluorescence; Cell imaging

Categories

Funding

  1. National Natural Science Foundation of China [21771065]
  2. Guangdong Special Support Program [2017TQ04R138]
  3. Natural Science Foundation of Guangdong Province, China [2019A1515012021]
  4. Pearl River Nova Program of Guangzhou, Guangdong Province, China [201806010189]

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Hydrogen peroxide, as a typical reactive oxygen species, has attracted increasing interest in biochemical field. Researchers have developed a fluorescent probe BOD-H2O2 for highly sensitive and selective detection of H2O2, and it can visualize endogenous H2O2 in cells.
Hydrogen peroxide (H2O2), as a typical reactive oxygen species (ROS), has attracted increasing interest in biochemical field since its homeostasis has recognized implications with diverse health and diseases consequences. The detection of H2O2 is crucial to accurately understand its roles in the physiological and pathological process. Here, we develop a fluorescent probe BOD-H2O2 with its excitation and emission lying in the near infrared (NIR) region for highly sensitive and selective detecting H2O2. Upon treated with H2O2, BOD-H2O2 demonstrated a significant turn-on fluorescent signal and a high selectivity towards H2O2 over other cellular abundant competitive ROS. The probe BOD-H2O2 can also be applied to visualize endogenous H2O2 with NIR cellular imaging, providing a potent tool for tracking the H2O2 in biological environments.

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