Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 141, Issue 4, Pages 1087-1095Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2020.11.006
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- Walgreens Boots Alliance
- National Institute for Health Research Manchester Biomedical Research Centre (Manchester, United Kingdom)
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Inflammaging, a chronic low-level inflammation associated with aging, is believed to drive many age-associated conditions. This condition also affects the structure and function of the skin, making it more susceptible to damage.
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed to drive many age-associated conditions, including dementia, arthritis, and type 2 diabetes. As with other organs, the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well-understood. This review article describes the evidence for inflammaging in the skin, its relationship with senescence, and how this relates to declining skin structure and function.
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