Journal
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
Volume 63, Issue 2, Pages 283-296Publisher
WILEY
DOI: 10.1111/jipb.13032
Keywords
cell death; classification; coiled‐ coil domain; disease resistance; NLR; structure
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This review outlines the current understanding of NLR CC domains in terms of diversity, classification, structure, their roles in cell death induction, disease resistance, and interaction with other proteins. Possible directions for future work are also provided.
Plant nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen avirulence effectors and activate defense responses. Nucleotide-binding, leucine-rich repeat receptors are classified into coiled-coil (CC)-containing and Toll/interleukin-1 receptor (TIR)-containing NLRs. Recent advances suggest that NLR CC domains often function in signaling activation, especially for induction of cell death. In this review, we outline our current understanding of NLR CC domains, including their diversity/classification and structure, their roles in cell death induction, disease resistance, and interaction with other proteins. Furthermore, we provide possible directions for future work.
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