Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 223, Issue -, Pages S276-S282Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa700
Keywords
microbiome; fecal microbiota transplantation; FMT; microbiome drugs; microbiome therapeutics
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH)
- Centers for Disease Control and Prevention (CDC)
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The transfer of live gut microbes may revolutionize the treatment of various diseases, with fecal microbiota transplantation showing early success in certain infections. The development of microbiome drugs is now being driven by these clinical advances, although challenges remain in terms of safety, consistency, and delivery.
The transfer of live gut microbes may transform patient care across a range of autoimmune, metabolic, hepatic, and infectious diseases. One early approach, fecal microbiota transplantation, has shown promise in Clostridiodes difficile infection and the potential for improving clinical and public health outcomes for other antibiotic-resistant bacteria. These clinical successes have motivated the development of microbiome drugs, which will need to address challenges in safety, uniformity, and delivery while seeking to preserve the benefits of using whole microbiome communities as novel therapeutics and an innovative platform for drug discovery.
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