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Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
Paolo P. Provenzano et al.
CANCER CELL (2012)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Haoqiang Ying et al.
CELL (2012)
Breathless cancer cells get fat on glutamine
Dimitrios Anastasiou et al.
CELL RESEARCH (2012)
Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Tewfik Hamidi et al.
CLINICAL CANCER RESEARCH (2012)
The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression
Kotaro Miyake et al.
EXPERIMENTAL CELL RESEARCH (2012)
Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment
Vanessa Rausch et al.
JOURNAL OF PATHOLOGY (2012)
Energy metabolism and proliferation in pancreatic carcinogenesis
Ivonne Regel et al.
LANGENBECKS ARCHIVES OF SURGERY (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
Mert Erkan et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)
Epigenetics and the environment: emerging patterns and implications
Robert Feil et al.
NATURE REVIEWS GENETICS (2012)
MUC1 regulates PDGFA expression during pancreatic cancer progression
M. Sahraei et al.
ONCOGENE (2012)
Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential
Alexei V. Salnikov et al.
PLOS ONE (2012)
Hypoxia-Inducible Factor-1α Regulates Chemotactic Migration of Pancreatic Ductal Adenocarcinoma Cells through Directly Transactivating the CX3CR1 Gene
Tiansuo Zhao et al.
PLOS ONE (2012)
Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species
Maura Calvani et al.
PLOS ONE (2012)
MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Nina V. Chaika et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
Alexandre Cassago et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells
Kshama R. Jaiswal et al.
STEM CELL RESEARCH (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells
Takashi Kojima et al.
EXPERIMENTAL CELL RESEARCH (2011)
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
Katrien De Bock et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2011)
Pancreatic cancer: understanding and overcoming chemoresistance
Zhiwei Wang et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)
GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin
S. Inaguma et al.
ONCOGENE (2011)
Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1 alpha-Dependent Manner in Pancreatic Cancer Cells
Okito Hashimoto et al.
PATHOBIOLOGY (2011)
β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness
Ester Sanchez-Tillo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypoxia-reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2
Marcelo G. Binker et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
Y. Su et al.
BRITISH JOURNAL OF CANCER (2010)
Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma
K. K. Y. Cham et al.
BRITISH JOURNAL OF CANCER (2010)
Hypoxia inducible factors in cancer stem cells
J. M. Heddleston et al.
BRITISH JOURNAL OF CANCER (2010)
Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling and Reduces Hypoxia in Tumors
Junpei Sasajima et al.
CANCER RESEARCH (2010)
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
Ahmed Mohyeldin et al.
CELL STEM CELL (2010)
The role of HIF prolyl hydroxylases in tumour growth
Terhi Jokilehto et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
Johanna Chiche et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer
David L. Schwartz et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Anne Le et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Selective Killing of Hypoxia-Inducible Factor-1-Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer
Shinae Kizaka-Kondoh et al.
CLINICAL CANCER RESEARCH (2009)
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications
Hideharu Hashimoto et al.
EPIGENETICS (2009)
Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer
Masao Kawamoto et al.
HUMAN PATHOLOGY (2009)
The Ape-1/Ref-1 Redox Antagonist E3330 Inhibits the Growth of Tumor Endothelium and Endothelial Progenitor Cells: Therapeutic Implications in Tumor Angiogenesis
Gang-Ming Zou et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Role of cancer stem cells in pancreatic ductal adenocarcinoma
Gregory Sergeant et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2009)
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
J. M. Bailey et al.
ONCOGENE (2009)
Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect
Yijun Chen et al.
PLOS ONE (2009)
Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer
Peter Buechler et al.
NEOPLASIA (2009)
Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
Veronique Nogueira et al.
CANCER CELL (2008)
The novel hypoxic cell radio sensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer
Kotaro Miyake et al.
CANCER LETTERS (2008)
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells
Seung-Nam Jung et al.
CARCINOGENESIS (2008)
Mitochondrial complex III regulates hypoxic activation of HIF
T. Klimova et al.
CELL DEATH AND DIFFERENTIATION (2008)
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration
Gang-Ming Zou et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang et al.
NATURE CELL BIOLOGY (2008)
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
Sian Jones et al.
SCIENCE (2008)
Hypoxia, DNA repair and genetic instability
Robert G. Bristow et al.
NATURE REVIEWS CANCER (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
S. Julien et al.
ONCOGENE (2007)
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
Patrick C. Hermann et al.
CELL STEM CELL (2007)
PKCδ and tissue transglutarninase in pancreatic cancer cells are novel inhibitors of autophagy
Bulent Ozpolat et al.
AUTOPHAGY (2007)
Epithelial to mesenchymal transition: Expression of the regulators snail, slug, and twist in pancreatic cancer
Birgit Hotz et al.
CLINICAL CANCER RESEARCH (2007)
Hypoxia-inducible factors, stem cells, and cancer
Brian Keith et al.
CELL (2007)
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
Ryo Fukuda et al.
CELL (2007)
Surgery for recurrent pancreatic ductal adenocarcinoma
Joerg Kleeff et al.
ANNALS OF SURGERY (2007)
Selective tumor targeting by the hypoxia-activated prodrug AQ4N blocks tumor growth and metastasis in preclinical models of pancreatic cancer
Alshad S. Lalani et al.
CLINICAL CANCER RESEARCH (2007)
Identification of pancreatic cancer stem cells
Chenwei Li et al.
CANCER RESEARCH (2007)
Reactive oxygen species: A breath of life or death?
John P. Fruehauf et al.
CLINICAL CANCER RESEARCH (2007)
NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells:: potential involvement of ZEB-1 and ZEB-2
H. L. Chua et al.
ONCOGENE (2007)
Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
Takao Ide et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
HS Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor
M Wang et al.
ONCOGENE (2005)
Signal pathway of hypoxia-inducible factor-1α phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells
SJ Kwon et al.
CLINICAL CANCER RESEARCH (2005)
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells -: Implication of natural antisense HIF-1α
T Uchida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine
K Yokoi et al.
CLINICAL CANCER RESEARCH (2004)
Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in a human pancreatic cancer cell line, KP4
F Hirai et al.
ANTIOXIDANTS & REDOX SIGNALING (2004)
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail
J Ikenouchi et al.
JOURNAL OF CELL SCIENCE (2003)
Dominant-negative hypoxia-inducible factor-1α reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
J Chen et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Reactive species mechanisms of cellular hypoxia-reoxygenation injury
CY Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)
Pancreatic tumors show high levels of hypoxia
AC Koong et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2000)