Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 401, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2020.123390
Keywords
Biomarker; Health risk assessment; Polycyclic aromatic hydrocarbons; Phthalates; Urine
Categories
Funding
- National Natural Science Foundation of China [41991310, 41977303]
- Fundamental Research Funds for the Central Universities of China [20ykpy87]
- 100 Top Talent Programs of Sun Yat-sen University
- Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Z032]
- Medical Scientific Research Foundation of Guangdong Province, China [A2018173]
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The study found variations in the concentrations of OH-PAHs and mPAEs in urine based on geographical location, and a positive correlation between 8-OHdG and these substances. OH-PAHs were found to contribute more to oxidative DNA damage when present alongside mPAFs. Risk assessment indicated that while risks from PAHs may be negligible, a significant percentage of school children may face health risks from PAEs, particularly diethylhexyl phthalate.
Monohydroxylated polycyclic aromatic hydrocarbons (OH-PAHs), phthalate metabolites (mPAFs), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the urine of school children aged 8-11 years from Shenzhen, China were measured in order to investigate oxidative stress damage from co-exposure to PAHs and PAEs. The concentrations of OH-PAHs and mPAEs in urine were 0.36-36.5 (median: 3.86) and 9.48-1609 (median: 240) ng/mL respectively. Gender and age did not influence urinary concentrations of Sigma OH-PAHs and EmPAEs, but geographical variations (i.e., urban versus suburban) were observed. Levels of 8-OHdG were positively correlated with urinary OH-PAHs and mPAEs, with correlation coefficients (r) varying between 0.160 and 0.365 (p < 0.05). OH-PAHs made a greater contribution to oxidative DNA damage than mPAFs when these two types of pollutants were present at the same concentrations. Human health risks were assessed using the hazard quotient and the hazard index for the cumulative risk of a complex of chemicals. The results demonstrated that risks from PAHs could be neglected, but that 29.5 % of school children may be subject to obvious health risks from PAEs, especially diethylhexyl phthalate.
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