Journal
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
Volume 35, Issue 1, Pages 24-37Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988720973759
Keywords
psychosocial stress; dementia; Alzheimer disease (AD); posttraumatic stress disorder (PTSD); socioeconomic status (SES); vital exhaustion (VE); longitudinal studies
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This systematic review examines the association between psychosocial stress and late onset dementia, and provides some suggestive evidence supporting this association. However, due to the low quality of evidence, further robust and longitudinal studies are needed to strengthen or refute these findings.
Stress has deleterious effects on brain health and yet, the prognostic value of psychosocial stress regarding the most common types of dementias, including Alzheimer disease, is still unclear. The primary aim of this systematic review was to explore the association between psychosocial stress and late onset dementia. We classified 24articles from Medline, PsycINFO, CINAHL, and Web of Science, as pertaining toxic categories of psychosocial and trauma-related stress (low socio-economic status [SES] related inequalities, marital status, posttraumatic stress disorder, work stress, vital exhaustion [VE], and, combined stressors). Using the Quality of Prognosis Studies in Systematic Reviews tool, we judged the quality of evidence to be low. This systematic review provided some non-robust, yet suggestive evidence that the above psychosocial types of stress are associated with increased risk of dementia in later life. Future robust, longitudinal studies with repeated validated measures of psychosocial stress and dementiaare required to strengthen or refute these findings.
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