In vitro reduction of mycotoxin deoxynivalenol by organic adsorbent

The contamination of feeds and foods with mycotoxins is a serious problem worldwide. Deoxynivalenol (DON), an important mycotoxin from the trichothecene family, is abundant in animal feed. Mycotoxin binders such as Lactic acid bacteria (LAB) detoxify mycotoxins by adsorption and inactivate the toxins through the formation of mycotoxin-organic adsorbent complex or act as biomarkers to convert the toxins into less toxic products. In this study, the effect of organic adsorbent containing Lactobacillus strains and the cell wall of the yeast Saccharomyces cerevisiae was investigated on the reduction of DON. Various parameters including toxin concentration, adsorbent type, incubation time, and the synergism effect were also studied. The detoxification ability was demonstrated in all strains but the combination of Lactobacillus brevis TD4 and Lactobacillus paracasei TD3 in PBS solution and L. brevis TD4 and L. brevis TD10 in MRS broth medium showed the highest reduction rate of DON. Novelty Impact Statement Deoxynivalenol causes devastating effects on animal health as well as agricultural products such as decreased milk yield and lower quality of dairy products. In the current study, the detoxification ability of mycotoxin-organic binders including Lactobacillus and yeast cell wall was investigated and the combination of Lactobacillus brevis TD4 and Lactobacillus paracasei TD3 in PBS solution and L. brevis TD4 and L. brevis TD10 in MRS broth medium showed the highest reduction rate of DON.

Automated summary

This study investigates the detoxification ability of mycotoxin-organic binders, including Lactobacillus and yeast cell wall, on reducing DON contamination. The combination of Lactobacillus brevis TD4 and Lactobacillus paracasei TD3 in PBS solution and L. brevis TD4 and L. brevis TD10 in MRS broth medium showed the highest reduction rate of DON.