Journal
JOURNAL OF FOOD BIOCHEMISTRY
Volume 45, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/jfbc.13584
Keywords
antioxidant potential; bulk lipid autoxidation; curcumin; DFT calculations; hydroxylated biphenyls
Funding
- Bulgarian Academy of Sciences and Consiglio Nazionale delle Ricerche (BAS-CNR) [0012242 23/02/2016]
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Curcumin's multi-target activity makes it a promising candidate for drug development. Monomeric and dimeric analogues exhibit significant antioxidant properties and synergistic effects, enhancing the antioxidant status. Analogues with a biphenyl skeleton show potential in various applications, such as in food chemistry and medicine.
The multi-target activity of curcumin makes it a promising pharmacological lead for structural modifications focused on the preparation of new better therapeutics with improved bioavailability. A possible modification is to decompose the parent curcumin structure into constituent units and to build up curcumin analogues with biphenyl structural moiety. The antioxidant properties of the so-called monomers (m1-m3) and dimers (d1-d3) are studied experimentally and computationally. Their protective effects as chain-breaking antioxidants are investigated for the individual compounds and in binary/ternary compositions with alpha-tocopherol (TOH) and ascorbyl palmitate (AscPH). All monomers manifest significant synergism up to 70% in mixtures with TOH. Synergistic effects are found for the ternary compositions of monomeric analogues upon addition to the binary mixture of standard antioxidants (TOH + AscPH). Dimers with biphenyl skeleton manifest a lower potential in compositions under lipid oxidation conditions. DFT computations provide a detailed insight into the structure and antiradical properties of the curcumin analogues and standard antioxidants. Practical applications Bioactive compounds in the diet play a crucial role in the prevention of numerous diseases in whose pathogenesis oxidative stress is well known to be involved. Therefore, enhancement of the antioxidant status of the biological target is often helpful. Two of the monomers studied are considered leading agents in the treatment or prophylaxis of smooth muscle disorders and are useful in the maintenance of the normal gut function- as a calmative for the gut and to ease upset stomach. We hypothesized that the presence of a biphenyl scaffold in the parent molecular structure can enhance the biological activity. Equimolar mixtures of TOH with studied compounds have potential application in food chemistry and medicine. A composition comprising the active agent and additional components (strong conventional antioxidants) may be administered in foodstuffs, as a food supplement, beverage supplement, or as a pharmaceutical composition.
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