Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 36, Issue 1, Pages 257-269Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2020.1862099
Keywords
Plectranthus; antioxidant; tyrosinase; collagenase; elastase
Funding
- FCT - Fundacao para a Ciencia e Tecnologia [PEst-OE/SAU/UI4013/2014, UID/DTP/04567/2016, UIDB/04567/2020, UIDP/04567/2020, FPU 2019]
- University of Alcala
- Fundação para a Ciência e a Tecnologia [UIDP/04567/2020, UIDB/04567/2020] Funding Source: FCT
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The study found that extracts from Plectranthus spp. plants have antioxidant and inhibitory effects on skin-related enzymes, with certain isolated compounds showing significant activity against tyrosinase and elastase.
A series of Plectranthus spp. plant extracts (aqueous, acetonic, methanolic and ethyl acetic) obtained from eight different species, and previously isolated compounds (ranging from polyphenols, diterpenes and triterpenes), were assayed for in vitro inhibition of the skin-related enzymes tyrosinase, collagenase and elastase, and for studying their antioxidant properties. The ethyl acetic extracts of P. grandidentatus and P. ecklonii registered the highest antioxidant activity, whereas acetonic, methanolic and ethyl acetic extracts of P. ecklonii, P. grandidentatus, P. madagascariensis and P. saccatus concerning the enzymatic inhibition assays revealed high anti-tyrosinase and anti-collagenase activities. From the isolated compounds tested, abietane diterpenes and triterpenes were highly active against tyrosinase and elastase activity. Overall, the experimental results showed the powerful antioxidant and inhibitory action on skin-related enzymes tyrosinase, collagenase and elastase of Plectranthus spp. extracts and/or isolated compounds, supporting their further research as bioactive metabolites against skin sagging and hyperpigmentation in cosmetic and pharmaceutical formulations.
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