Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 32, Issue 2, Pages 164-173Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2020.1866741
Keywords
Atopic dermatitis; systemic therapy; patient-reported outcomes; quality of life
Categories
Funding
- Sanofi Genzyme
- Regeneron Pharmaceuticals, Inc.
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The EUROSTAD study enrolled 308 adult patients with moderate-to-severe AD, with an average age of 37 years and a disease duration of 25 years. Most patients used systemic therapy and experienced high disease severity and burden, as well as borderline or clinical levels of anxiety and/or depression.
Background: Insights into the real-world treatment paradigm and long-term burden of atopic dermatitis (AD) are needed to inform clinical and health policy decisions. Methods: The prospective, observational EUROSTAD study enrolled adults with moderate-to-severe AD starting or switching systemic therapy (51 sites in 10 European countries). We report the baseline characteristics, treatment patterns, and outcomes of these patients using descriptive statistics. Results: A 12-month enrollment period of EUROSTAD was completed and 308 patients were enrolled: average age 37 years, AD duration 25 years, 43% were female. Most patients reported use of systemic therapy (93%) and >= 1 atopic comorbidity (82%). Mean [standard deviation] disease severity/burden measures were high: Investigator's Global Assessment (3.1 [0.8]), Eczema Area and Severity Index (16.2 [10.9]), Peak Pruritus Numerical Rating Scale (5.5 [2.5]), sleep impairment Visual Analog Scale (49.8 [31.6]) scores, and time lost from work (4.1 [13.7] days/year) or usual activities (16.8 [38.7] days/year). Most patients showed borderline or clinical levels of anxiety (59%) and/or depression (63%) using the Hospital Anxiety and Depression Scale. Conclusions: Adults with moderate-to-severe AD starting/switching systemic treatment enrolled in EUROSTAD have a high burden of longstanding disease despite continuous use of topical drugs, emollients, and systemic therapies.
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