Journal
JOURNAL OF CRANIOFACIAL SURGERY
Volume 32, Issue 2, Pages 794-798Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SCS.0000000000007003
Keywords
Collagen membrane; in vivo assessments; peripheral nerve; platelet-rich fibrin; tissue regeneration
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The study evaluated the effects of leucocyte/platelet-rich fibrin (L-PRF) with or without a collagen membrane on crushed sciatic nerve healing in a rat model. The combination of L-PRF with collagen membrane showed relatively positive effects on nerve recovery, indicating potential benefit in nerve regeneration.
Alternative treatment approaches to improve the regeneration ability of damaged peripheral nerves are currently under investigation. The aim of the current study was to evaluate the effects of leucocyte/platelet-rich fibrin (L-PRF) with or without a collagen membrane as a supporter on crushed sciatic nerve healing in a rat model. Recovery of motor function and electrophysiologic measurements were evaluated at 4 weeks postoperatively. The whole number of myelinated axons, peripheral nerve axon density, average nerve fiber diameter (mu m), and G-ratio were analyzed and compered among the groups. Functional, electrophysiological, and histological evaluations showed no significant difference among the groups with the exception of the L-PRF with collagen membrane groups that showed relatively positive effects on the functional and histological nerve recovery. In addition, the collagen membrane with L-PRF can be effect in nerve regeneration.
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