4.3 Article

Synthesis, crystal structure, and urease inhibition of an end-on azido-bridged dinuclear copper(II) complex with an oxidized tridentate Schiff base ligand

Journal

JOURNAL OF COORDINATION CHEMISTRY
Volume 74, Issue 4-6, Pages 1028-1038

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2020.1861603

Keywords

Schiff base; copper complex; crystal structure; α -C activation; urease inhibition

Funding

  1. high-level cultivation project of Liaoning Normal University [GD19L005]

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A dinuclear copper(II) complex with end-on azido-bridges has been successfully prepared and characterized. Unexpected oxidation of the original ligand was observed during the preparation process. The complex exhibited excellent urease inhibitory activity.
An end-on azido-bridged dinuclear copper(II) complex, [Cu2L2(mu(1,1)-N-3)(2)], where L is the deprotonated form of N-(2-hydroxy-4-methoxybenzylidene)picolinamide (HL), has been prepared by the reaction of 5-methoxy-2-[(pyridin-2-ylmethylimino)methyl]phenol (HL ') with copper bromide and sodium azide in methanol. The structure of the complex was characterized by elemental analysis, IR and UV-vis spectra, and single crystal X-ray diffraction. The complex possesses crystallographic inversion symmetry, with the two Cu ions (3.36 angstrom) bridged by two end-on azido bridges. Each Cu ion is in a square pyramidal coordination. The original ligand HL ' was unexpectedly oxidized to HL under mild conditions during preparation of the complex. The complex has excellent urease inhibitory activity.

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