Journal
JOURNAL OF CONTROLLED RELEASE
Volume 328, Issue -, Pages 100-111Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2020.08.035
Keywords
Hypoxia-responsive; Iron oxide clusters; Reactive oxygen species; Chemodynamic therapy; Photodynamic therapy
Funding
- National Natural Science Foundation of China [81902535, 81972350]
- China Postdoctoral Science Foundation [2019_M651896]
- clinical medical special Program of Science and Technology Project of Jiangsu Province [BE2019734]
Ask authors/readers for more resources
Single reactive oxygen species (ROS)-mediated therapy, photodynamic therapy (PDT) or chemodynamic therapy (CDT) is severely hindered in hypoxic solid tumor. Herein, to address the urgent challenge, a hypoxia-activated ROS burst liposome has been fabricated to achieve synergistic PDT/CDT that is initiated by the structural dissociation of poly(metronidazole) liposome in hypoxic tumor microenvironment (TME). The therapeutic enhancement of our ROS-blasting treatment is simultaneously regulated by external light-initiated PDT and endogenous iron oxide nanoclusters-triggered CDT, which is synergistically boosted and amplified by localized mild hyperthermia under 808/660 nm coirradiation. More importantly, in vitro and in vivo experiments demonstrate that electron-affinic poly(aminoimidazole) product from hypoxia-responsive transition of poly(metronidazole) polymers could efficiently enhance hypoxic cell apoptosis and induce solid tumor ablation. Thus, this work offers a potential hypoxia-activated ROS burst-PDT/CDT strategy with a superior antitumor efficacy, highlighting a promising clinical application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available