Journal
JOURNAL OF CLINICAL PATHOLOGY
Volume 74, Issue 8, Pages 475-482Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jclinpath-2020-207029
Keywords
breast diseases; immunoglobulins; inflammation
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Immunoglobulin G4-related sclerosing mastitis (IgG4-RM) is a rare disease that predominantly occurs in middle-aged women, presenting with painless palpable mass and/or lymphadenopathy, which can be mistaken for breast cancer. Data on IgG4-RM is limited due to its rarity, emphasizing the importance of further research and understanding of this condition.
Immunoglobulin G4-related sclerosing mastitis (IgG4-RM) is a recently recognised member of the IgG4-related disease (IgG4-RD) family, a multisystem fibroinflammatory condition that can affect any organ system. IgG4-RM is rare and predominantly occurs in middle-aged women. It may present with painless palpable mass and/or lymphadenopathy thereby mimicking breast cancer. Although there is an abundance of literature describing the clinicopathological characteristics of IgG4-RD in a variety of organs, data on IgG4-RM are limited due to its rarity. This review describes the manifestation of the disease in the breast based on reported cases, emphasising the clinicopathological features, pathophysiology, differential diagnosis, treatment and prognosis.
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