Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 59, Issue 2, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02510-20
Keywords
ELISA; SARS-CoV-2; antibodies; oral fluid; rapid test; saliva; serology
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The study found that the OraSure oral fluid total antibody detection test had comparable sensitivity and specificity to commercially available serum-based ELISAs for SARS-CoV-2 antibody detection, while also allowing for a more accessible form of specimen collection with the potential for self-collection.
Current commercially available methods for reliably detecting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain expensive and inaccessible due to the need for whole-blood collection by highly trained phlebotomists using personal protective equipment (PPE). We have evaluated an antibody detection approach using the OraSure Technologies oral antibody collection device (OACD) and their proprietary SARS-CoV-2 total antibody detection enzyme-linked immunosorbent assay (ELISA). We found that the OraSure test for total antibody detection in oral fluid had comparable sensitivity and specificity to commercially available serum-based ELISAs for SARS-CoV-2 antibody detection while allowing for a more accessible form of specimen collection with the potential for self-collection.
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