Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 106, Issue 4, Pages 1101-1110Publisher
ENDOCRINE SOC
DOI: 10.1210/clinem/dgaa956
Keywords
hypothyroidism; hyperthyroidism; twin studies; genetics
Categories
Funding
- County Council of Varmland
- County Council of Stockholm
- Swedish Society for Medical Research
- Ake Wiberg Foundation
- Swedish Research Council
- Novo Nordisk Foundation
Ask authors/readers for more resources
Hashimoto's thyroiditis (HT) and Graves' disease (GD) have a modest genetic relationship, with genetic factors playing a more significant role in men's susceptibility to HT compared to women.
Context: Hashimoto's thyroiditis (HT) and Graves' disease (GD) are known to coaggregate in families, but the magnitude and nature of a shared etiology is unknown. Objectives: To estimate the shared genetic influence on overt HT and GD and to examine if the heritability differs between men and women. Design, setting, and patients: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swedish twins. By comparing intra-class and cross-twin cross-trait correlations in dizygotic and monozygotic twins, we calculated heritability and the proportions thereof shared between the diseases. Univariate estimates of heritability were calculated by sex. Results: The heritability for HT and GD was 65% (95% CI, 61-70) and 63% (95% CI, 55-72), respectively. The genetic correlation was 0.35 (95% CI, 0.20-0.50) and shared genetic effects accounted for 8% of the variance for both HT and GD. Univariate heritability was significantly higher in men than in women for HT (90% vs 60%, P < 0.001) but not for GD (79% vs 63%, P = 0.085). Conclusions: From a genetic perspective, HT and GD appear to be only modestly related diseases. Hence, the term autoimmune thyroid disease, used to cluster these disorders, may have limited validity in a genetic context. Moreover, the mechanisms contributing to HT are partly different for the sexes, with genetic components more important in men.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available