Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1634, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2020.461661
Keywords
SFC; Hydroxychloroquine; Chiral preparative separation; Covid-19; Enantiocel C2-5
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A robust supercritical chromatography (SFC) method using an Enantiocel C2-5 column was developed for the multigram separation of the enantiomers of hydroxychloroquine (HCQ), affirming its use as a scalable technology and ability to provide quantities of each enantiomer for clinical evaluation. The enantiomers of HCQ were collected on a gram scale with greater than 99% enantiomeric excess. The S and R enantiomer elution order was confirmed using optical rotation determinations with comparison to previously determined assignments. (C) 2020 Elsevier B.V. All rights reserved.
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