Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1636, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2020.461785
Keywords
Metabolomics; nanoparticles; enrichment; chemoselective probe; stationary phase; MALDI imaging
Funding
- National Natural Science Foundation of China [21904057]
- National Key Research and Development Program of China [2019YFC1605100]
- DICP, CAS [DICPQIBEBT UN201806]
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Metabolomics focuses on studying the changes of metabolites in biological systems, and nanomaterials play a crucial role in improving the selectivity, separation performance, detection sensitivity, and identification efficiency of metabolites when mass spectrometry is used as the detection technique.
Metabolomics systematically studies the changes of metabolites in biological systems in the temporal or spatial dimensions. It is a challenging task for comprehensive analysis of metabolomics because of diverse physicochemical properties and wide concentration distribution of metabolites. Used as enrichment sorbents, chemoselective probes, chromatographic stationary phases, MS ionization matrix, nanomaterials play excellent roles in improving the selectivity, separation performance, detection sensitivity and identification efficiency of metabolites when mass spectrometry is employed as the detection technique. This review summarized the recent development of nanoparticle-assisted metabolites analysis in terms of assisting the pretreatment of biological samples, improving the separation performance and enhancing the MALDI-MS detection. (C) 2020 Elsevier B.V. All rights reserved.
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