Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 26, Issue 6, Pages 1785-1798Publisher
WILEY
DOI: 10.1111/jcmm.16102
Keywords
biomarker; cancer; circular RNAs; immunity; therapy
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Funding
- Science and Technology Commission of Shanghai [18ZR1403900]
- National Natural Science Foundation of China [81872895]
- Pudong Hospital Fudan University School of Pharmacy Joint Fund [RHJJ2018-03]
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Circular RNAs (circRNAs) are a class of closed loop structures formed by covalent bonds of head and tail, and play important roles in regulating gene transcription and translation. They have been found to contribute to cancer development and have potential as biomarkers and therapeutic targets. Furthermore, circRNAs are involved in immune regulation and antitumor immunotherapy.
Circular RNAs (circRNAs) are a class of single-stranded RNAs with closed loop structures formed by covalent bonds of head and tail. Exploration of circRNAs is continually increasing; however, their functional relevance largely remains to be elucidated. In general, they are stable, abundant, conserved and expressed in tissue-specific manner. These distinct properties and their diverse cellular actions indicate that circRNAs modulate transcription and translation, and may even function as translation templates. Growing evidence reveals that circRNAs contribute to various physiological and pathological processes, including the initiation and progression of cancer. In this review, we present the current knowledge about circRNAs in cancer development, as well as their potential for use as biomarkers and even therapeutic targets. CircRNA's role in immune regulation and antitumour immunotherapy is also discussed. In addition, possible challenges in antitumour therapy are raised, and current progress and future perspectives are provided.
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