Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 109, Issue 7, Pages 949-960Publisher
WILEY
DOI: 10.1002/jbm.b.34759
Keywords
cardiomyocyte; human pluripotent stem cells; maturation; synthetic microenvironments
Funding
- National Natural Science Foundation of China [81571824]
- Chengguan District Science and Technology Project [2018-7-6]
- Fundamental Research Funds for the Central Universities [lzujbky-2015-295 lzujbky-2018-27]
- Gansu Province Science Foundation for Youths [18JR3RA295]
- Lanzhou University Hospital of Stomatology Research Support Fund [LZUKQKY-2019-Y10 lzukqky-2019-t9]
- Young Elite Scientist Sponsorship Program by CSA [2018QNRC001]
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Various approaches, including genetic manipulation, biochemical factors supplement, mechanical stress, electrical stimulation, and three-dimensional culture, have been developed to promote the maturation of cardiomyocyte like cells derived from human pluripotent stem cells. Establishing synthetic artificial microenvironments based on the in vivo development program of cardiomyocytes has gained attention for their potential to accelerate maturation.
Cardiomyocyte like cells derived from human pluripotent stem cells (hPSC-CMs) have a good application perspective in many fields such as disease modeling, drug screening and clinical treatment. However, these are severely hampered by the fact that hPSC-CMs are immature compared to adult human cardiomyocytes. Therefore, many approaches such as genetic manipulation, biochemical factors supplement, mechanical stress, electrical stimulation and three-dimensional culture have been developed to promote the maturation of hPSC-CMs. Recently, establishing in vitro synthetic artificial microenvironments based on the in vivo development program of cardiomyocytes has achieved much attention due to their inherent properties such as stiffness, plasticity, nanotopography and chemical functionality. In this review, the achievements and deficiency of reported synthetic microenvironments that mainly discussed comprehensive biological, chemical, and physical factors, as well as three-dimensional culture were mainly discussed, which have significance to improve the microenvironment design and accelerate the maturation of hPSC-CMs.
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