Inspiratory muscle training in neuromuscular patients: Assessing the benefits of a novel protocol

BACKGROUND: Neuromuscular diseases are characterized by the compromise of respiratory muscles, thoracic ventilation, muscle strength and coughing capacity. Patients have low quality of life and increased morbidity and mortality mostly due to respiratory impairment. OBJECTIVE: To assess the benefits of adding inspiratory muscle training to neuromuscular patients' treatment and their compliance to the approach. METHODS: We conducted a single-center prospective study with neuromuscular patients with decreased maximal inspiratory pressure. We developed an inspiratory muscle training protocol with three-month duration and once-daily training. The protocol had a progressive intensity that was individually tailored based on patients' baseline characteristics and tolerance. We used Powerbreathe Medic Classic devices to perform the training. RESULTS: There were 21 patients who met the inclusion criteria and were enrolled in the study. Muscular dystrophy (n = 12, 57.3%) and amyotrophic lateral sclerosis (n = 4, 19%) were the most common diseases. After three months of training, patients increased their maximal inspiratory muscle pressure (p = 0.002) and peak cough flow (p = 0.011). Compliance to the protocol was 99 +/- 5.5%. CONCLUSIONS: This protocol showed significant improvements on pulmonary muscles function and might be considered as an adjunct treatment to neuromuscular treatment. However, these positive results require larger further studies to validate the clinical benefits long-term.

Automated summary

The study demonstrated that incorporating inspiratory muscle training into the treatment of neuromuscular patients can significantly improve their respiratory function and coughing capacity, with high compliance to the training protocol. Further larger studies are needed to validate the long-term clinical benefits.