Journal
JOURNAL OF APPLIED MICROBIOLOGY
Volume 130, Issue 6, Pages 2063-2074Publisher
OXFORD UNIV PRESS
DOI: 10.1111/jam.14918
Keywords
B vitamins; breast tumour; immunomodulation; intestinal mucositis; probiotic
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Funding
- CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas) [PIP 0697]
- ANPCyT (Agencia Nacional de Promocion Cientifica y Tecnologica) [0301, 2554]
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The selected LAB mixture as a co-adjuvant for chemotherapy showed promising results in reducing side-effects and providing essential nutrients, which could potentially improve the outcomes of conventional oncologic therapies.
Aims To evaluate a mixture of selected lactic acid bacteria (LAB) (a riboflavin-producer, a folate-producer and an immunomodulatory strain) as co-adjuvant for 5-fluorouracil (5-FU) chemotherapy in cell culture and using a 4T1 cell animal model of breast cancer. Methods and results The viability of Caco-2 cells exposed to 5-FU and/or LAB was analysed. Mice bearing breast tumour were treated with 5-FU and/or LAB. Tumour growth was measured. Intestinal mucositis (IM) was evaluated in small intestine; haematological parameters and plasma cytokines were determined. The bacterial mixture did not negatively affect the cytotoxic activity of 5-FU on Caco-2 cells. The LAB mixture attenuated the IM and prevented blood cell decreases associated with 5-FU treatment. Mice that received 5-FU and LAB mixture decreased tumour growth and showed modulation of systemic cytokines modified by both tumour growth and 5-FU treatment. The LAB mixture by itself delayed tumour growth. Conclusions The mixture of selected LAB was able to reduce the side-effects associated with chemotherapy without affecting its primary anti-tumour activity. Significance and Impact of the Study This bacterial mixture could prevent the interruption of conventional oncologic therapies by reducing undesirable side-effects. In addition, this blend would provide essential nutrients (vitamins) to oncology patients.
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