Related references
Note: Only part of the references are listed.MST1: a promising therapeutic target to restore functional beta cell mass in diabetes
Amin Ardestani et al.
DIABETOLOGIA (2016)
Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice
Michael Shum et al.
DIABETOLOGIA (2016)
Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
Katherine H. Schreiber et al.
AGING CELL (2015)
Pancreatic β-Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
Alberto Bartolome et al.
DIABETES (2014)
Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
Rinke Stienstra et al.
DIABETOLOGIA (2014)
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
Amin Ardestani et al.
NATURE MEDICINE (2014)
Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes
Etty Bachar-Wikstrom et al.
DIABETES (2013)
Evidence for Rapamycin Toxicity in Pancreatic beta-Cells and a Review of the Underlying Molecular Mechanisms
Adam D. Barlow et al.
DIABETES (2013)
mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells
Olivier Le Bacquer et al.
JOURNAL OF ENDOCRINOLOGY (2013)
Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
Pengda Liu et al.
NATURE CELL BIOLOGY (2013)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
mTORC1 signaling and regulation of pancreatic β-cell mass
Manuel Blandino-Rosano et al.
CELL CYCLE (2012)
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming et al.
SCIENCE (2012)
Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells
Angela M. Farrelly et al.
APOPTOSIS (2011)
Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
Yanyun Gu et al.
DIABETES (2011)
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport
Kazuaki Ohtsubo et al.
NATURE MEDICINE (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
Laura R. Pearce et al.
BIOCHEMICAL JOURNAL (2010)
mTOR and cancer: many loops in one pathway
Alejo Efeyan et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
Linyuan Wang et al.
DIABETES (2010)
Autophagy in human type 2 diabetes pancreatic beta cells
M. Masini et al.
DIABETOLOGIA (2009)
Glucose Amplifies Fatty Acid- Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1
Etti Bachar et al.
PLOS ONE (2009)
Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
Hye Seung Jung et al.
CELL METABOLISM (2008)
mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
Merav Fraenkel et al.
DIABETES (2008)
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
Nadine S. Sauter et al.
ENDOCRINOLOGY (2008)
Biphasic response of pancreatic β-cell mass to ablation of tuberous sclerosis complex 2 in mice
Yutaka Shigeyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
Frederic Tremblay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Functional and molecular defects of pancreatic islets in human type 2 diabetes
S Del Guerra et al.
DIABETES (2005)
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells
I Briaud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
RP Robertson et al.
DIABETES (2004)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
SH Um et al.
NATURE (2004)
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
P Marchetti et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
AE Butler et al.
DIABETES (2003)
Share Paper
