Journal
DIABETOLOGIA
Volume 59, Issue 12, Pages 2613-2621Publisher
SPRINGER
DOI: 10.1007/s00125-016-4090-5
Keywords
Coffee; Dairy; Fibre; Gene-environment interaction; GIPR; Incretins; KCNQ1; Olive oil; TCF7L2; WFS1
Categories
Funding
- EU [LSHM_CT_2006_037197]
- YTvdS: Dutch research council (NWO-ZonMW) [40-00812-98-10040]
- NL Agency [IGE05012]
- Board of the UMC Utrecht
- EA: Health Research Fund (FIS) of the Spanish Ministry of Health
- Navarre Regional Government
- CIBER Epidemiologia y Salud Publica (CIBERESP)
- GB: Spanish Ministry of Health (ISCIII RETICC RD) [06/0020/0091]
- Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
- PWF: Swedish Research Council
- Novo Nordisk
- Swedish Diabetes Association
- Swedish Heart-Lung Foundation
- RK: German Cancer Aid
- German Ministry of Research (BMBF)
- TJK: Cancer Research UK
- KTK: Medical Research Council UK
- Cancer Research UK
- CN: Health Research Fund (FIS) of the Spanish Ministry of Health
- Murcia Regional Government [6236]
- PMN: Swedish Research Council
- KO: Danish Cancer Society
- OR: The Vasterboten County Council
- YTvdS
- IS
- AMWS
- DLvdA: Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF), Statistics Netherlands
- AT: Danish Cancer Society
- RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government
- ER: Imperial College Biomedical Research Centre
- MRC [MC_UU_12015/1] Funding Source: UKRI
- Medical Research Council [MC_UU_12015/1, MC_UU_12015/5] Funding Source: researchfish
Ask authors/readers for more resources
The gut incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) have a major role in the pathophysiology of type 2 diabetes. Specific genetic and dietary factors have been found to influence the release and action of incretins. We examined the effect of interactions between seven incretin-related genetic variants in GIPR, KCNQ1, TCF7L2 and WFS1 and dietary components (whey-containing dairy, cereal fibre, coffee and olive oil) on the risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study. The current case-cohort study included 8086 incident type 2 diabetes cases and a representative subcohort of 11,035 participants (median follow-up: 12.5 years). Prentice-weighted Cox proportional hazard regression models were used to investigate the associations and interactions between the dietary factors and genes in relation to the risk of type 2 diabetes. An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]). In addition, an interaction (p = 0.005) between an incretin-specific genetic risk score and coffee was observed, again with a stronger inverse association with coffee in carriers with more risk alleles (0-3 risk alleles: HR 0.99 [95% CI 0.94, 1.04]; 7-10 risk alleles: HR 0.95 [95% CI 0.90, 0.99]). None of these associations were statistically significant after correction for multiple testing. Our large-scale case-cohort study provides some evidence for a possible interaction of TCF7L2 variants and an incretin-specific genetic risk score with coffee consumption in relation to the risk of type 2 diabetes. Further large-scale studies and/or meta-analyses are needed to confirm these interactions in other populations.
Reviews
Recommended
No Data Available
Share Paper
