Developing and evaluating a pediatric asthma severity computable phenotype derived from electronic health records

Background: Extensive data available in electronic health records (EHRs) have the potential to improve asthma care and understanding of factors influencing asthma outcomes. However, this work can be accomplished only when the EHR data allow for accurate measures of severity, which at present are complex and inconsistent. Objective: Our aims were to create and evaluate a standardized pediatric asthma severity phenotype based in clinical asthma guidelines for use in EHR-based health initiatives and studies and also to examine the presence and absence of these data in relation to patient characteristics. Methods: We developed an asthma severity computable phenotype and compared the concordance of different severity components contributing to the phenotype to trends in the literature. We used multivariable logistic regression to assess the presence of EHR data relevant to asthma severity. Results: The asthma severity computable phenotype performs as expected in comparison with national statistics and the literature. Severity classification for a child is maximized when based on the long-term medication regimen component and minimized when based only on the symptom data component. Use of the severity phenotype results in better, clinically grounded classification. Children for whom severity could be ascertained from these EHR data were more likely to be seen for asthma in the outpatient setting and less likely to be older or Hispanic. Black children were less likely to have lung function testing data present. Conclusion: We developed a pragmatic computable phenotype for pediatric asthma severity that is transportable to other EHRs. (J Allergy Clin Immunol 2021;147:2162-70.)

Automated summary

The study developed and evaluated a standardized pediatric asthma severity phenotype based on clinical asthma guidelines for use in EHR-based health initiatives and studies. Findings showed that severity classification based on long-term medication regimen was most effective, leading to better classification of asthma severity in patients.