Journal
INTERNATIONAL PSYCHOGERIATRICS
Volume 33, Issue 11, Pages 1135-1144Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1041610220003841
Keywords
aging; memory; neuropsychology; MoCA; CANTAB; PAL
Funding
- NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation [22293]
- CAMH
- Peter & Shelagh Godsoe Endowed Chair in Late-Life Mental Health
- CAMH Foundation and Discovery Fund
- National Institute of Aging
- Brain Canada
- Canadian Institutes of Health Research
- Alzheimer's Drug Discovery Foundation
- Ontario Brain Institute
- Centre for Aging and Brain Health Innovation
- Bright Focus Foundation
- Alzheimer's Society of Canada
- W. Garfield Weston Foundation
- Weston Brain Institute
- Canadian Consortium on Neurodegeneration in Aging
- Genome Canada
- Brain and Behavior Research Foundation
- BrightFocus Foundation
- Canada Foundation for Innovation
- Canada Research Chair
- National Institutes of Health
- Ontario Ministry of Research and Innovation
- Centre for Ageing and Brain Health Innovation
- Centre for Addiction and Mental Health
- University of Toronto
- Ontario Ministry of Health and Long-Term Care
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The study found a strong association between performance on the PAL task and global cognition, with the PAL task showing high sensitivity and specificity in differentiating patients with Alzheimer's Dementia from healthy comparators. This suggests that the PAL task may serve as a valuable screening tool for AD.
Objective: Appropriate screening is integral to the early diagnosis and management of Alzheimer's Dementia (AD). The Paired Associates Learning (PAL) task is a digital cognitive task that is free of cultural, language, and educational biases. This study examined the association between the PAL task performance and global cognition and the usefulness of the PAL task as a screening tool for AD. Design: Cross-sectional. Setting: Academic hospital. Methods: Twenty-five participants with AD and 22 healthy comparators (HC) were included. The Cambridge Neuropsychological Test Automated Battery PAL task and the Montreal Cognitive Assessment (MoCA) were used to assess cognition. We assessed the relationship between the PAL task and MoCA performance using Pearson correlation and linear regression. We also examined the PAL task's ability to distinguish between AD and HC participants using Receiver Operating Characteristic curve (ROC) analysis. Measurements: MoCA Total Score had a strong positive correlation with PAL Stages Completed score (r = 0.8, p < 0.001), and a strong negative correlation with PAL Total Errors (adjusted) score (r = -0.9, p < 0.001). Further, PAL Total Errors (adjusted) score predicted the MoCA Total Score (F (4, 46) = 37.2, p < 0.001). On ROC analysis, PAL Total Errors (adjusted) score cut-off of 54 errors had 92% sensitivity and 86% specificity to detect AD. Conclusions: Performance on the PAL task is highly associated with global cognition. Further, the PAL task can differentiate patients with AD from HCs with high sensitivity and specificity. Thus, the PAL task may hold potential usage as an easy-to-administer screening tool for AD.
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